Michele De Lucchi was born in 1951 in Ferrara and graduated in architecture in Florence. During the period of radical and experimental architecture he was a prominent figure in movements like Cavart, Alchimia and Memphis.
He has designed lamps and furniture for the most known Italian and European companies, as Artemide, Olivetti, Alias, Unifor, Hermès, Alessi. For Olivetti he has been Director of Design from 1988 to 2002 and he developed experimental projects for Compaq Computers, Philips, Siemens and Vitra and he elaborated various personal theories on the evolution of the workplace. 

He designed and restored buildings in Japan for NTT, in Germany for Deutsche Bank, in Switzerland for Novartis, and in Italy for Enel, Olivetti, Piaggio, Poste Italiane, Telecom Italia. In 1999 he has been appointed to renovate some of ENEL's (the Italian Electricity Company) power plants. For Deutsche Bank, Deutsche Bundesbahn, Enel, Poste Italiane, Telecom Italia, Hera, Intesa Sanpaolo and at other Italian and foreign banks he has collaborated to the evolution of the corporate image, introducing technical and aesthetic innovation into the working environments.

He has curated numerous art and design exhibitions as well as designing buildings and exhibition systems for museums such as the Triennale di Milano, the Palazzo delle Esposizioni in Rome, the Neues Museum in Berlin, the Fondazione Cini in Venice and the Gallerie d’Italia - Piazza Scala, the PietĂ  Rondanini museum and Casa Manzoni in Milan. 
He developed many architectural projects for private and public client in Georgia, as Ministry of Internal Affairs and the Bridge of Peace in Tbilisi. 

He has realized a number of projects for the city of Milan: the pavilions for Expo 2015 (Padiglione Zero, Expo Center, Intesa Sanpaolo) and UniCredit Pavilion in piazza Gae Aulenti. In 2017 the Garage Italia creative centre was opened inside an historical petrol station that has been completely restored under the guidance of Michele De Lucchi.

Michele De Lucchi is currently designing luxury resorts in various parts of the world: in Georgia, China, Japan and in Italy. 

His professional work has always gone side-by-side with a personal exploration of design, technology and crafts. From 2004 he has been sculpturing  little  wooden houses  with the chain saw to create  the essentiality of the  architectural style.

In 2003 the Centre Georges Pompidou in Paris has acquired a considerable number of his works. Selections of his products are exhibited in the most important design Museums in Europe, United States and Japan. 

In 2000 he was appointed Officer of Italian Republic by President Ciampi, for services to design and architecture. In 2001 he has been nominated Professor at the Design and Art Faculty at the University in Venice. In 2006 he received the Honorary Doctorate from Kingston University, for his contribution to “living quality”.In 2008 he has been nominated Professor at the Design Faculty of the Politecnico of Milan and Member of the Accademia Nazionale di San Luca in Rome. He has been editor in chief of the new “Domus” for the year 2018. The first of the 10 architects who will take turns to lead the magazine until 2028.

Michele De Lucchi is founder and member of AMDL CIRCLE, a multidisciplinary group of thinkers and innovators. Since 2018, AMDL CIRCLE focuses on Earth Stations, future sharing architectures that combine technological development with humanist principles.